The Ruger SR22 or SR22P is a rimfire semi-automatic pistol chambered for the .22 Long Rifle cartridge, manufactured by Sturm, Ruger & Co.. The SR22 is mainly targeted at plinking and competition shooting.

The SR22 does not share design and ergonomic commonalities with the striker-fired centerfire Ruger SR-Series pistols and mechanically deviates significantly. In fact, it is more similar to the Walther P22 than a Ruger SR-Series pistol. The SR22 comes only in compact size, although recently a 4.5 inch barrel version (Model 3620) was released.

The SR22 has a straight blowback-type action, and features a stainless steel barrel that is fixed to the frame. Furthermore, the SR22 features a double-action/single-action trigger system with a rounded-spur external hammer, and has a visual inspection port in the form of a hole in the top of the slide and the back of the barrel that functions as a loaded chamber indicator. The pistol is very lightweight thanks to its aluminium slide and polymer frame, and also comes with interchangeable rubber grips for different-sized hands. The SR22 started to ship in January 2012 and is shipped with two single stack 10-round magazines and replaceable grips for small or large hands.

The Ruger SR22 is equipped standard with an ambidextrous thumb safety/decocking lever, and magazine release. Two interchangeable handgrips are offered. One in slim, and the other in wide-palmswell format. It is also equipped with a Picatinny rail on the frame below the barrel and in front of the trigger guard.