.22-250 Remington is a very high-velocity (capable of reaching over 4000 feet per second), short action, .22 caliber rifle cartridge.  Primarily used for varmint hunting and small game hunting. It finds occasional use on deer. This cartridge is also sometimes known as the .22 Varminter or the .22 Wotkyns Original Swift.  Along with the .220 Swift, the .22-250 was one of the high-velocity .22 caliber cartridges that developed a reputation for remote wounding effects known as hydrostatic shock in the late 1930s and early 1940s.

The .22-250 is currently the fastest production cartridge, surpassing the .204 Ruger. This round is loaded by Hornady under their Superformance line and is a 35 grain, non-toxic, fragmenting varmint bullet at 4450 feet per second (1356 m/s) from a 24″ barrel.